dextran sulfate sodium
Dextran sulfate sodium (DSS) with a mol. wt. of approx. 40000 when administered orally in the drinking water has been found to induce colitis in experimental animals. Concentrations from 2 to 5% have been used and symptoms develop within one week. The recommended concentrations of DSS for mice are 2.5-3.5% and this will depend, eg. on the ...
About SODIUM DEXTRAN SULFATE: Sodium Dextran Sulfate is a sodium salt of the sulfuric acid ester of Dextran (q.v.).. Function(s): Suspending Agent - Nonsurfactant; GEL FORMING; VISCOSITY CONTROLLING Synonym(s): DEXTRAN SULFURIC ACID ESTER SODIUM SALT; DEXTRAN, HYDROGEN SULFATE, SODIUM SALT; HYDROGEN SULFATE SODIUM SALT DEXTRAN; SODIUM SALT DEXTRAN, HYDROGEN SULFATE; ASURO; DEXNON; DEXTRAN ...
What 's the mechanism of dextran sodium sulfate (DSS) on inducing colitis model? Hi, Normally, people establish the mice colitic model by treating the mice with DSS, but I want to ask, why DSS ...
Dextran sulfate sodium salt from Leuconostoc spp. for molecular biology, average Mw >500,000 (dextran starting material), contains 0.5-2% phosphate buffer; CAS Number: 9011-18-1; find Sigma-Aldrich-D8906 MSDS, related peer-reviewed papers, technical documents, similar …
Dextran sulfate sodium is used to study colitis (inflammatory bowel disease) as well as an antiviral agent. It functions as a nonsurfactant, suspending agent with gel forming and viscosity controlling properties. It can be used in gels and moisturizers.
MP Premium Dextran Sulfate Sodium Salt from MP Biomedicals is one of the most widely used product based on peer reviewed scientific publications. Over the past 15 years 3,000+ scientific publications have cited the use of our DSS. Hence when you select one of our DSS offerings, you can be assured of the performance based on qual-
Dextran Sulfate Sodium Salt: Safety and Handling CAUTION! Emergency Overview May cause skin, eye, and respiratory tract irritation. Use personal protective equipment. Ensure adequate ventilation. Wash off immediately with plenty of water for at least 15 minutes. Get medical attention immediately if symptoms occur.
Among the different animal models developed to help in understanding IBDs pathophysiological mechanisms as well as to achieve pharmacological preclinical studies, the dextran sulfate sodium (DSS)-induced colitis model is the most widely used because of its simplicity, cost-effectiveness, and similarity with human IBDs.
Dextran sulfate sodium (DST-H): All Experiments and Citations in CPDB. The definition of each code in the plot below will appear in a pop-up window when the field name in the header line is clicked, e.g., Strain, Site, Path. Each numbered line starts a new experiment and reports protocol information in black.
Experimental colitis induced by dextran sulphate sodium in mice:beneficial effects of sulphasalazine and olsalazine. Aliment Pharmacol Ther 1998; 12:925–934. Miceli R, Hubert M, Santiago G, Yao D, Coleman T, Huddleston KA and Connolly K. Efficacy of keratinocyte growth factor-2 in dextran sulfate sodium-induced murine colitis.
Dextran sulfate sodium salt may be used as an accelerant to decrease the time required for probe annealing. DSS may be included in the hybridization buffer when the rate of hybridization is a limiting factor in detecting rare sequences or it may be included in the hybridization buffer when a limited amount of probe is available. DSS also ...
dextran sulfate: the sodium salt of sulfuric acid esters of the polysaccharide dextran; it contains not less than 10 units per mg and not less than 14% of sulfate; an anticoagulant.
May 14, 2012· Lu F, Fernandes SM, Davis AE., III The role of the complement and contact systems in the dextran sulfate sodium-induced colitis model: the effect of C1 inhibitor in inflammatory bowel disease. American Journal of Physiology. 2010; 298 (6):G878–G883.
Dextran sulfate sodium salt is a kind of organic sulfur containing sugar medicine, is a kind of white or light yellow powder, hygroscopic, slightly sweet and salty. Easily soluble in water, acid, water solution microscopic pH5.2 ~ 6.5. [applications] Dextran sulfate sodium salt of this rising star drugs.
Detralfate. Detralfate [INN] Detralfatum [INN-Latin] Detralfato [INN-Spanish] Dextran sulfate sodium aluminium
Dextran sulfate is a polyanionic derivative of dextran produced by esterification of Dextran with chlorosulphonic acid. The sulfur content is approximately 17% which corresponds to an average of 1.9 sulfate groups per glucosyl residue of the dextran molecule.Dextran sulfate sodium (DSS) is the…
Material Safety Data Sheet. Dextran sulfate, sodium salt ACC# 61051 Section 1 - Chemical Product and Company Identification: MSDS Name: Dextran sulfate, sodium salt Catalog Numbers: 61136-1000, BP1585-100, BP1585-500 Synonyms: Dextran Sodium Sulfate Company Identification: Fisher Scientific ...
Inflammatory bowel diseases (IBDs), primarily ulcerative colitis and Crohn's disease, are inflammatory disorders caused by multiple factors. Research on IBD has often used the dextran sodium sulfate (DSS)-induced colitis mouse model. DSS induces in vivo but not in vitro intestinal inflammation. In addition, no DSS-associated molecule (free glucose, sodium sulfate solution, free dextran ...
Dextran sulfate sodium salt Mr ~40,000; find Sigma-Aldrich-42867 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich.
Dextran sulfate (dextran hydrogen sulfate, sodium salt) has been tested as a potential substitute for heparin in anticoagulant therapy. Following studies by Ingelman, Walton and Ricketts explored the anticoagulant properties of a wide range of dextran sulfates (Mw 7000 to 458000) and established that the lowest molecular weight products ...
Part 1: Injury-Repair Colitis Model. Baseline weight should be obtained for each mouse prior to beginning DSS treatment. Make a 3% (w/v) Dextran Sulfate Sodium Salt solution in water and filter with a 0.45 μm cellulose acetate filter.
dextran sulfate sodium (Inert or Nuisance Dust: (d) Respirable fraction) 5 US OSHA Permissible Exposure Levels (PELs) - Table Z3 dextran sulfate sodium (Inert or Nuisance Dust: (d) Total dust) 15 US - Hawaii Air Contaminant Limits dextran sulfate sodium (Particulates not other wise regulated - Total dust) 10 US - Hawaii Air Contaminant Limits ...
Dextran sulfate sodium (DSS) can be used to study colitis (inflammatory bowel disease) as well as an antiviral as agent. Several animal models have been used to study colitis and one such model involves the oral administration of dextran sulphate sodium salt (DSS) in …
SAFETY DATA SHEET Creation Date 19-Jul-2010 Revision Date 18-Jan-2018 Revision Number 3 1. Identification Product Name Dextran sulfate, sodium salt No. : BP1585-100; BP1585-500 Synonyms Dextran Sodium Sulfate Recommended Use Laboratory chemicals. Uses advised against Not for food, drug, pesticide or biocidal product use Details of the supplier of the safety data sheet
Dextran, a chemical used experimentally to induce colitis in rodents Dioctyl sodium sulfosuccinate, a lubricant, laxative, and pesticide Dimethyl-silapentane-sulfonate, chemical compound used in spectroscopy for calibration
Perhaps the most widely used mouse model of colitis employs dextran sodium sulfate (DSS), a chemical colitogen with anticoagulant properties, to induce disease. DSS is a water-soluble, negatively charged sulfated polysaccharide with a highly variable molecular weight ranging from 5 to 1400 kDa.
These models are indispensable tools to decipher underlying mechanisms of IBD pathogenesis as well as to evaluate a number of potential therapeutics. Among various chemically induced colitis models, the dextran sulfate sodium (DSS)‐induced colitis model is widely used because of its simplicity and many similarities with human ulcerative colitis.
Dextran sulfate sodium (DSS)-induced colitis is a widely used experimental inflammation model to assess the functions of various molecules in the colon. By the following protocol, the extent of leukocyte infiltration in DSS-induced experimental colitis in WT and KO mice is examined. 1.
Dextran sulfate is an anionic polymer of sulfated glucose, capable of accelerating hybridization rates of nucleic acids. The polyanionic character of Dextran sulfate helps to approximate nucleic acid strands, increasing their effective concentration to each other and promoting hybridization.
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